張杰
1978年4月3日生，現(xiàn)就職于廈門大學(xué)醫(yī)學(xué)院，廈門大學(xué)特聘教授,博士生導(dǎo)師
主要榮譽：國家杰出青年科學(xué)基金，國家優(yōu)秀青年科學(xué)基金，教育部新世紀(jì)優(yōu)秀人才，福建省杰出青年基金，福建省青年拔尖人才，福建省高等學(xué)校新世紀(jì)優(yōu)秀人才，廈門市五四青年獎?wù)?，廈門大學(xué)特聘教授，廈門大學(xué)南強青年拔尖人才
教育工作經(jīng)歷:
l1997年9月-2001年7月,四川大學(xué)，生命科學(xué)學(xué)院，學(xué)士
l2001年9月-2006年7月,中國科學(xué)院生物物理研究所，博士
l2006年9月-2009年6月，美國新澤西州立大學(xué)，細(xì)胞與神經(jīng)科學(xué)學(xué)系，博士后
l2009年6月-2011年8月，美國新澤西州立大學(xué)，細(xì)胞與神經(jīng)科學(xué)學(xué)系，研究助理
l2011年8月-至今，廈門大學(xué)醫(yī)學(xué)院，教授，博士生導(dǎo)師
研究工作簡介
張杰博士長期從事重大神經(jīng)系統(tǒng)疾?。ɡ夏臧V呆、抑郁癥、自閉癥、術(shù)后認(rèn)知障礙）等的發(fā)病機制和藥物開發(fā)研究。至今以第一作者或者通訊作者在國際知名期刊發(fā)表研究論文20余篇,平均影響因子7.8，H-index 17。其中回國獨立開展研究工作以后，作為通訊作者在Nature Neuroscience, Neuron，Biological Psychiatry, PNAS, Cell Reports, The Journal of Neuroscience, Clinical Cancer Research，Cell Death and Disease, JBC, Chemistry，Chem. Biol. Drug Des.等雜志上發(fā)表多篇研究論文。
主持人才、科研基金、以及獲獎情況
l國家自然科學(xué)基金 器官衰老與器官退行性變化重大研究計劃-重點項目，胰島素抵抗誘導(dǎo)神經(jīng)元衰老及在老年癡呆發(fā)生發(fā)展中的作用、91849205，2019/01-2022/12，200萬
l國家杰出青年科學(xué)基金，阿爾茨海默病的分子機制研究，81925010，2020/01-2024/12，400萬
l國家自然科學(xué)基金 促進海峽兩岸科技合作基金 重點項目，CDK3調(diào)控阿爾茨海默病中神經(jīng)元死亡的機制及干預(yù)研究，U1905207，2020/01-2023/12，270萬。
l國家自然科學(xué)優(yōu)秀青年基金，81522016、阿爾茨海默病的致病機制研究、2016/01-2018/12，130萬
l教育部“新世紀(jì)優(yōu)秀人才”，50萬NCET-13-0508
l福建省“高等學(xué)校新世紀(jì)優(yōu)秀人才”，30萬
l福建省杰出青年科學(xué)基金，2014J06019、老年癡呆疾病中Cdk5調(diào)控因子P35和P25的神經(jīng)功能差異研究、30萬。
l國家自然科學(xué)基金面上項目，81271421、阿爾茨海默病中CDK5對神經(jīng)元細(xì)胞周期紊亂的作用和機制研究、70萬
l國家自然科學(xué)基金面上項目，31571055、Cdk5磷酸化Bag3及其在神經(jīng)元突觸功能和凋亡中的作用與機制研究，64萬
l福建省衛(wèi)生教育聯(lián)合攻關(guān)計劃，40萬
l橫向課題，“肌醇生物功效的深入開發(fā)研究”、200萬
l廈門大學(xué)校長基金、團隊基金、交叉基金（250萬）
l2016-2019，國家重點研發(fā)計劃2016YFC1305900
代表性文章:
1.Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang* CDK5-dependent BAG3 degradation modulates synaptic protein turnover. Biological Psychiatry. 2020, 87(8):756-769.
2.Hei-man Chow, Meng Shi, Aifang Cheng, Yuehong Gao, Guimiao Chen, Xuan Song, Raphaella Wai Lam So, Jie Zhang*, Karl Herrup*Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. Nature Neuroscience. 2019, 22(11):1806-1819.
3.Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guangyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin*, Jie Zhang*. CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis. J Exp Clin Cancer Res. 2019, 38(1):286.
4.Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu,* and Jie Zhang* Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron 2018, 100(3):551-563
5.Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang* Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression. Cell Reports 2018, 24, 701–712
6.Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yuehong Gao, Jiechao Zhou, Yun-wu Zhang, Guojun Bu, Maoqiang Xue*, Jie Zhang* Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell Death Dis. 2018, 9(10):951.
7.Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang* The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death. The Journal of Neuroscience 2015, 35(6):2624-2635
8.Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang* Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research 2015, 21(6):1419-1428
9.Hei-man Chow, Dong Guo, Jiechao Zhou, Gunagyun Zhang, Huifang Li, Karl Herrup, Jie Zhang*. CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci (USA). 2014, 111(45):E4887-4895
10.Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang * Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE. Chem. Biol. Drug Des. 2014, 83(1):81-88.
11.Jie Zhang*, Huifang Li, Tingwen Zhou, Jiechao Zhou, Karl Herrup*. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase, J Biol. Chem. 2012, 287(31): 25985-25994
12.Jie Zhang, Karl Herrup*, Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle 2011, 10(8): 1208-1214
13.Jie Zhang, Huifang Li, Karl Herrup*. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. The Journal of Neuroscience 2010, 30:5219-5228
14.Jie Zhang, Huifang Li, Karl Herrup*. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation, J. Biol. Chem. 2010, 285(18): 14052-14061
15.Jie Zhang, Samantha Cicero, Li Wang, Romito-Digiacomo, R.R., Yan, Yang, Karl Herrup* Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons. Proc. Nat. Acad. Sci. (USA) 2008, 105: 8772-8777
16.Jie Zhang, Karl Herrup. Cdk5 and the non-catalytic arrest of the neuronal cell cycle, Cell Cycle 2008, 7:3487-3490
17.Qiang Liu#, Jie Zhang#, Hua Zhu, Chuna Qin, Qi Chen, Baolu Zhao*, Dissecting the signaling pathway of nicotine-mediated Nneuroprotection in amouse Alzheimer disease model. FASEB J. 2007, 21(1): 61-73(#Equal contribution)
18.Jie Zhang, Qiang Liu, Nian-Qing Liu, Fu-Liang Li, Qi Chen, Chuan Qin, Hua Zhu, Yu-Ying Huang, Wei He, Bao-Lu Zhao*, Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J. 2006, 20(8):1212-1224
19.Jie Zhang, Xue-Fei Wang, Zhong-Bing Lu, Nian-Qing Liu, Bao-Lu Zhao, The effects of meso-2, 3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Free Radic. Biol. Med. 2004, 37:1037-1050
20.Li Wang, Jie Zhang, Karl Herrup Cdk5 may be an atypical kinase, but not in the way you think, Cdk5 book, Ip, N. and Tsai, L-H, eds., Springer.
社會兼職:
中國神經(jīng)科學(xué)學(xué)會神經(jīng)內(nèi)穩(wěn)態(tài)和內(nèi)分泌分會副主任委員
中國生物物理學(xué)會自由基生物學(xué)與醫(yī)學(xué)專業(yè)委員會常務(wù)理事
Pharmacological Research, Consulting Editor
