許韌
醫(yī)學(xué)博士后、教授、博士生導(dǎo)師，細(xì)胞應(yīng)激生物學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室課題組長(zhǎng),“閩江學(xué)者”特聘教授，國(guó)際華人骨研學(xué)會(huì)終身會(huì)員、美國(guó)和日本骨代謝學(xué)會(huì)會(huì)員、獲得中國(guó)駐日本大使館-中國(guó)學(xué)友會(huì)會(huì)長(zhǎng)榮譽(yù)證書、日本文部省（教育部） 全球杰出計(jì)劃-“超級(jí)學(xué)生” 稱號(hào)、國(guó)際華人骨研學(xué)會(huì)（ICMRS）Webster Jee青年學(xué)者獎(jiǎng)、國(guó)際骨免疫年會(huì)-青年學(xué)者獎(jiǎng)、美國(guó)骨代謝研究學(xué)會(huì)（ASBMR）青年學(xué)者獎(jiǎng)、美國(guó)骨研究促進(jìn)會(huì)（AIMM）John Haddad青年學(xué)者獎(jiǎng)、廈門大學(xué)“南強(qiáng)青年拔尖人才”-A類、中組部青年千人-會(huì)評(píng)（新冠疫情延期中）。近年來，骨骼系統(tǒng)與機(jī)體其他組織/器官之間的偶聯(lián)機(jī)制逐漸成為系統(tǒng)生物學(xué)研究的新興熱點(diǎn)，也是進(jìn)行精準(zhǔn)醫(yī)學(xué)治療所必須明確的核心內(nèi)容。許韌博士一直聚焦于骨形成細(xì)胞與其支撐系統(tǒng)的交流機(jī)制，深入探究成骨微環(huán)境的調(diào)控功能和潛在的臨床價(jià)值。其中以第一作者身份在Nature、Nature Medicine和JBMR等國(guó)際知名期刊上均發(fā)表研究成果。
目前實(shí)驗(yàn)室致力的主要研究方向如下：
1）骨特異性神經(jīng)/血管體系在骨骼退行性疾病中的作用機(jī)制
2）成骨細(xì)胞來源細(xì)胞因子在機(jī)體能量代謝中的功能
3）骨骼干細(xì)胞/前體細(xì)胞在癌癥發(fā)生和骨轉(zhuǎn)移中的介導(dǎo)機(jī)制
主持科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目（8197090543），2020/01-2023/12，SLIT3介導(dǎo)的血管亞型在骨骼干細(xì)胞微環(huán)境中的作用機(jī)制研究，￥550,000，主持
2.廈門大學(xué)“南強(qiáng)青年拔尖A類人才”啟動(dòng)經(jīng)費(fèi)，￥3,000,000，主持
3.CornellUniversity-FFPI Grant, “Identification of Novel Mediators Governing Osteoblast-Type H Endothelial Cells Coupling”, 2015-2017，$100,000，主持.
已申請(qǐng)的專利：
美國(guó)專利：Matthew Greenblatt,Ren Xu and Laurie Glimcher, SLIT and Bone Growth Modulation (Filing, US 62/630,557) 2018
主要相關(guān)論著：
1.Li N, InoueK, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B,Xu R#, Greenblatt MB. Osteoclasts Are Not a Source of SLIT3. Bone Res. 2019 .
2.Ji G*,Xu R*, Niu Y, Li N, Ivashkiv L, Bostrom MPG, Greenblatt MB, Yang X. Vascular endothelial growth factor pathway promotes osseointegration and CD31(hi)EMCN(hi) endothelium expansion in a mouse tibial implant model: an animal study.Bone Joint J. 2019 Jul;101-B:108-114.
3.Xu R, Yallowitz A, Qin A, Wu Z, Shin D, Kim J, Debnath S, Ji G, Bostrom M, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos M, Wach A, Zhang Y, Inoue K, Lorenzo A, Zhao B, Butler J, Shim J, Glimcher L and Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss.Nature Medicine 2018 Jun;24(6):823-833.
4.Debnath S, Yallowitz A, McCormick J, Lalani S, Zhang T,Xu R, Li N, Liu Y, Yang Y, Eiseman M, Shim J, Hameed M, Healey J, Bostrom M, Landau D, Greenblatt MB. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing.Nature 2018 Oct;562(7725):133-139.
5. Inoue K, Deng Z, Chen Y, Giannopoulou E,Xu R, Gong S, Greenblatt MB, Mangala LS, Lopez-Berestein G, Kirsch DG, Sood AK, Zhao L, Zhao B. Bone protection by inhibition of microRNA-182.Nat Commun. 2018 Oct 5;9(1):4108.
6.Ji G, Han A, Hao X, Li N,Xu R, Wang F. Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique foranterior cruciate ligament reconstruction: a systematic review of comparativetrials.Arch Orthop Trauma Surg. 2018 Nov;138(11):1575-1581.
7.Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M,Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are criticalmediators of osteoblast activity in vivo.J Bone Miner Res. 2017 Sep;32(9):1811-1815.
8.Ma C, Fukuda T, Ochi H, Sunamura S, Xu C,Xu R, Okawa A, Takeda S. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.Mol Metab. 2015 Jan 21;4(3):175-85.
9.Xu R#. Semaphorin 3A: A new player in bone remodeling.Cell Adh Migr. 2014;8(1):5-10. Review.
10.Fukuda T*, Takeda S*,Xu R*, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations.Nature 2013 May 23;497(7450):490-3.
11.Wang M, Liu S, Li Y,Xu R, Lu C, Shen Y. Protoplast mutation and genome shuffling induce the endophytic fungusTubercularia sp. TF5 to produce new compounds.Curr Microbiol. 2010 Oct;61(4):254-60.
12. Inose H, Ochi H, Kimura A, Fujita K,Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K,Takeda S. A microRNA regulatory mechanism of osteoblast differentiation.Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20794-9.
13.Xu R, Wang M, Lu C, Shen Y. Tuberculariol A – C, new sesquiterpenes from mutant-741 ofTubercularia sp. TF5.Helv Chim Acta. 2009;92:1514-19.
14.Xu R, Lu C, Wu X, Lin C and Zheng Z. A new ten-membered lactone fromTubercularia sp. TF5, an endophytic fungus ofTaxus mairei.Chem. Nat. Compd. 2009;45; 6.
